Title:
ラパマイシン又はその誘導体を含有する医薬組成物
Document Type and Number:
Japanese Patent JP7020914
Kind Code:
B2
Abstract:
It is an object of the present invention to provide a pharmaceutical composition, which can suppress a reduction in the content of an active ingredient caused by oxidation or decomposition of rapamycin or a derivative thereof, can ensure long-term stability, and has high safety. In the present invention, the inventors have found that (B) a tocopherol derivative and (C) a phospholipid are used in a pharmaceutical formulation comprising rapamycin or a derivative thereof, so that oxidation or decomposition of the rapamycin or a derivative thereof can be suppressed, thereby completing the present invention. The rapamycin or a derivative thereof, and (B) the tocopherol derivative and (C) the phospholipid are preferably in the form of a solid mixture produced by preparing a solution containing these components and then removing the solvent from the solution.
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Inventors:
Futoshi Kawamura
Application Number:
JP2017539930A
Publication Date:
February 16, 2022
Filing Date:
September 14, 2016
Export Citation:
Assignee:
NIPPON KAYAKU KABUSHIKI KAISHA
International Classes:
A61K31/436; A61K47/22; A61K47/24; A61K47/26; A61K47/38
Domestic Patent References:
| JP2005537285A | ||||
| JP2002531527A | ||||
| JP55069688A | ||||
| JP2003512314A |
Foreign References:
| WO2000009085A1 | ||||
| CN101129361A |
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes