Title:
PHARMACEUTICAL COMPOSITION AND DIAGNOSIS METHOD FOR INFLAMMATORY SKIN DISEASE, DISORDER OR SYMPTOM
Document Type and Number:
Japanese Patent JP2014001231
Kind Code:
A
Abstract:
To provide a treatment method of a skin inflammatory disease, disorder or symptom.
Treatment or prevention of an inflammatory skin disease, disorder or symptom is carried out by modulating a protein normally controlled by caspase-8 in the skin or by increasing the activity or level of caspase-8 in the skin, where a medicament selected from (i) caspase-8 or its fragment, (ii) a polynucleotide encoding caspase-8 or its fragment and (iii) an expression vector comprising the polynucleotide of (ii) is locally administered.
Inventors:
DAVID WALLACH
KOVALENKO ANDREI
KANG TAE BONG
KIM JIN CHUL
KOVALENKO ANDREI
KANG TAE BONG
KIM JIN CHUL
Application Number:
JP2013180083A
Publication Date:
January 09, 2014
Filing Date:
August 30, 2013
Export Citation:
Assignee:
YEDA RES & DEVLOPMENT CO LTD
International Classes:
A61K38/46; A61K48/00; A61P17/02; A61P17/06; C12N9/50; C12N15/09
Domestic Patent References:
| JP2001516210A | 2001-09-25 | |||
| JP2004524010A | 2004-08-12 |
Foreign References:
| WO2005028664A2 | 2005-03-31 |
Other References:
J BIOL CHEM., VOL.278 NO.18 P.16183-16188 (2003), JPN6012010720, ISSN: 0002893857
J BIOL CHEM., VOL.279 NO.17 P.52824-52834 (2004), JPN6012010718, ISSN: 0002893858
J DERMATOL SCI., VOL.28 NO.3 P.187-197 (2002), JPN6014038152, ISSN: 0002893859
J BIOL CHEM., VOL.279 NO.17 P.52824-52834 (2004), JPN6012010718, ISSN: 0002893858
J DERMATOL SCI., VOL.28 NO.3 P.187-197 (2002), JPN6014038152, ISSN: 0002893859
Attorney, Agent or Firm:
Kawamura Taku
Yousuke Fujimori
Masahiro Mishima
Yousuke Fujimori
Masahiro Mishima