Title:
Ｂ型肝炎の予防または治療用医薬組成物
Document Type and Number:
Japanese Patent JP6811338
Kind Code:
B2
Abstract:
The present invention relates to a pharmaceutical composition for treating or preventing hepatitis B, comprising: at least one oligonucleotide selected from the group consisting an oligonucleotide represented by a nucleic acid sequence of SEQ ID NO: 1, 2, or 6 or a nucleic acid sequence complementary thereto; and an oligonucleotide having at least one chemical modification on the oligonucleotide, as an active ingredient, and a method for screening a therapeutic agent for hepatitis B according to the formation of a G-quadruplex by HBV and a candidate material. The pharmaceutical composition forms a G-quadruplex with HBV and reduces cccDNA (covalently closed circular DNA) and thus can be used in the treatment or prevention of hepatitis B.
Inventors:
Kim Kyun Fan
Kim Do Hyun
Park Young Min
Kim Do Hyun
Park Young Min
Application Number:
JP2019552439A
Publication Date:
January 13, 2021
Filing Date:
December 13, 2017
Export Citation:
Assignee:
AM Sciences, Inc.
International Classes:
A61K31/7088; A61K9/107; A61K9/127; A61K9/16; A61K9/51; A61K31/712; A61K31/7125; A61K47/30; A61K47/36; A61K48/00; A61P1/16; A61P31/20
Domestic Patent References:
| JP2014513954A |
Foreign References:
| CN1580070A | ||||
| US20010001098 |
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Koichiro Inami
Hidetoshi Hara
Ayako Seta
Koichiro Inami
Hidetoshi Hara