To obtain the subject composition capable of solubilizing a hydrophobic steroidal compound, enabling formation of preparation as an injection, capable of promoting absorbing property of an oral agent, or the like and useful as an antitumor agent by including a specific steroidal compound and a specific chitosan derivative.
This pharmaceutical composition comprises (A) a steroidal compound of formula I (R is a 1-13C alkyl) and (B) a chitosan derivative of formula II (R1 is H, or the like; R2 is H, or the like; deacetylation degree of N-acetyl represented in R1 is 70-100% and substitution degree of alkyl represented in R1 is 10-100% and substitution degree of carboxy-1-5C alkyl is 50-200% and molecular weight expressed in terms of carboxymethylchitin is ≥150,000) or its salt, preferably at a weight ratio of (1:0.5) to (1:5). The composition is preferably micelle-like aqueous composition or its dried composition.
YAMAHIRA TOMOHIRO
ISHIBE ATSUO
ITAI SHIGERU
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