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Patent Searching and Data


Title:
PHARMACEUTICAL COMPOSITION OF STEROIDAL COMPOUND
Document Type and Number:
Japanese Patent JPH11240836
Kind Code:
A
Abstract:

To obtain the subject composition capable of solubilizing a hydrophobic steroidal compound, enabling formation of preparation as an injection, capable of promoting absorbing property of an oral agent, or the like and useful as an antitumor agent by including a specific steroidal compound and a specific chitosan derivative.

This pharmaceutical composition comprises (A) a steroidal compound of formula I (R is a 1-13C alkyl) and (B) a chitosan derivative of formula II (R1 is H, or the like; R2 is H, or the like; deacetylation degree of N-acetyl represented in R1 is 70-100% and substitution degree of alkyl represented in R1 is 10-100% and substitution degree of carboxy-1-5C alkyl is 50-200% and molecular weight expressed in terms of carboxymethylchitin is ≥150,000) or its salt, preferably at a weight ratio of (1:0.5) to (1:5). The composition is preferably micelle-like aqueous composition or its dried composition.


Inventors:
MIWA AKIO
YAMAHIRA TOMOHIRO
ISHIBE ATSUO
ITAI SHIGERU
Application Number:
JP30837998A
Publication Date:
September 07, 1999
Filing Date:
October 29, 1998
Export Citation:
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Assignee:
TAISHO PHARMACEUTICAL CO LTD
International Classes:
A61K31/00; A61K31/575; A61K47/36; A61P35/00; C07J17/00; A61K9/107; (IPC1-7): A61K31/575; A61K9/107; A61K31/00; A61K47/36
Attorney, Agent or Firm:
Kitagawa Fuzo