Title:
PHARMACEUTICAL COMPOSITIONS FOR SUBCUTANEOUS ADMINISTRATION COMPRISING HUMAN HYALURONIDASE PH20 VARIANTS AND DRUGS
Document Type and Number:
Japanese Patent JP2023078146
Kind Code:
A
Abstract:
To provide pharmaceutical compositions comprising (a) a drug and (b) a human PH20 variant.SOLUTION: The human PH20 variant contained in the pharmaceutical composition of the invention comprises amino acid substitution at one or more sites selected from alpha helix 8 sequence (S347 to C381), and a linker region (A333 to R346) between alpha helix 7 and alpha helix 8 in the wild-type human PH20 having the amino acid sequence of SEQ ID NO: 1, where the amino acid located at the N terminus or the C terminus is selectively cleaved. The pharmaceutical composition of the invention may further contain a pharmaceutically acceptable additive, in particular a stabilizer. The pharmaceutical composition according to the present disclosure can maximize the therapeutic effect of the drug used in combination therewith, due to the effect of the human PH20 variant.SELECTED DRAWING: Figure 20
Inventors:
PARK SOON JAE
CHUNG HYE-SHIN
LEE SEUNG JOO
KIM KYUWAN
BYUN MINSOO
NAM KI SEOK
CHUNG HYE-SHIN
LEE SEUNG JOO
KIM KYUWAN
BYUN MINSOO
NAM KI SEOK
Application Number:
JP2023026863A
Publication Date:
June 06, 2023
Filing Date:
February 24, 2023
Export Citation:
Assignee:
ALTEOGEN INC
International Classes:
A61K45/00; A61K9/08; A61K31/7088; A61K31/7105; A61K35/12; A61K38/00; A61K38/47; A61K39/395; A61K47/02; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/22; A61K47/26; A61K47/40; A61K48/00; A61P43/00
Attorney, Agent or Firm:
Kenjiro Yamaguchi