Title:
筋変性疾患の治療用医薬組成物およびそのスクリーニング方法
Document Type and Number:
Japanese Patent JP4550394
Kind Code:
B2
Abstract:
An object of the present invention is to provide a method which is able to prevent or improve the progress of myolytic diseases such as muscular dystrophy. Such an object is able to be solved by a method where an effective dose of an inhibitor for hematopoietic prostaglandin D synthase (H-PGDS) or an antagonist to prostaglandin D receptor is administered to a patient who needs it. The present invention also provides a method for screening compounds which are able to prevent the progress of myolytic diseases and to improve it using human H-PGDS overexpressed transgenic mice.
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Inventors:
Yoshihiro Uraide
Naomi Eguchi
Kosuke Aritake
Yo Sato
Taniike Masako
Ikuko Mohri
Miyano Masashi
Naomi Eguchi
Kosuke Aritake
Yo Sato
Taniike Masako
Ikuko Mohri
Miyano Masashi
Application Number:
JP2003353917A
Publication Date:
September 22, 2010
Filing Date:
October 14, 2003
Export Citation:
Assignee:
Osaka Bioscience Institute
International Classes:
A61K31/454; G01N33/50; A01K67/027; A01N25/00; A01N43/42; A61K31/185; A61K31/403; A61K31/4166; A61K31/47; A61K31/501; A61K31/53; A61K45/00; A61P3/10; A61P9/10; A61P21/00; A61P21/04; A61P43/00; C12N15/85; C12N15/90; G01N33/15
Other References:
沖永剛志 ,筋繊維壊死過程における造血器型プロスタグランディンD合成酵素の発現,大阪大学医学雑誌,日本,2001年12月 5日,Vol.52,No.12,第2別冊,P.211-217
Kanaoka,Y. et al,Hematopoietic prostaglandin D synthase,Prostaglandins Leukot. Essent. Fatty Acids,2003年 9月,Vol.69,Issue 2-3,P.163-167
Kanaoka,Y. et al,Hematopoietic prostaglandin D synthase,Prostaglandins Leukot. Essent. Fatty Acids,2003年 9月,Vol.69,Issue 2-3,P.163-167
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Kyousei Tamura
Nagatoshi Shinagawa
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Kyousei Tamura
Nagatoshi Shinagawa