PHARMACEUTICAL COMPOSITION - TANABE SEIYAKU CO

Title:

PHARMACEUTICAL COMPOSITION

Document Type and Number:

Japanese Patent JP2000072675

Kind Code:

A

Abstract:

To obtain a pharmaceutical composition having excellent cGMP- specific phosphodiesterase inhibitory activity (PDE V-inhibiting activity) by compounding a specific isoquinoline derivative.

This pharmaceutical composition contains a compound of formula I {rings A and B are each a (substituted) benzene ring; R1 is H, a (substituted) lower alkyl, a (substituted) lower cycloalkyl, a (substituted) aryl, a (substituted) heterocyclic group or a (substituted) amino; R2 is a group of the formula: COOR3 (R3 is H or an ester residue) or the formula: CON(R4)(R5) [the group expressed by N(R4)(R5) is a (substituted) nitrogen-containing aliphatic heterocyclic group or a (substituted) amino group]} [e.g. 6-methoxy-3-methoxycarbonyl-2- morpholino-7-(4-pyridylmethyloxy)-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinoline]. The compound of formula I is obtained by reacting an isocoumarin derivative of formula II with an amine compound of the formula: R1NH2.

Inventors:

UKITA TATSUZO
OMORI KENJI
IKEO TOMIHIRO

Application Number:

JP24044698A

Publication Date:

March 07, 2000

Filing Date:

August 26, 1998

Export Citation:

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Assignee:

TANABE SEIYAKU CO

International Classes:

C07D217/26; A61K31/47; A61K31/472; A61K31/495; A61K31/535; A61K31/54; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P13/02; A61P15/00; A61P43/00; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D405/04; C07D405/06; C07D405/12; C07D409/12; C07D413/04; C07D491/056; (IPC1-7): A61K31/47; A61K31/47; A61K31/495; A61K31/535; A61K31/54; C07D217/26

Attorney, Agent or Firm:

Shigeo Minoura

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