Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
Japanese Patent JPS59104312
Kind Code:
A
Abstract:
There is presented a method, in the form of a dosage formulation, for transforming substantially orally inactive beta -lactam antibiotics or their pharmaceutically acceptable salts or the esters, ethers, or hydrates of said antibiotics or their salts into orally active compounds by combination of the chosen beta -lactam antibiotic with an enhancer comprising an aliphatic, preferably a C2 to C18, straight- or branched-chain, saturated or unsaturated, fatty acid or an aliphatic, preferably a C2 to C12, straight- or branched-chain, saturated or unsaturated, fatty acid mono-, di- or triglyceride or mixtures thereof, partial or total esters of propylene glycol, polyethylene glycol and carbohydrates of C2 to C12 fatty acids, as well as the pharmaceutically acceptable esters and ethers of said glycerides. The antibiotic and enhancer mixture may be administered orally as a solid dosage form with the beta -lactam antibiotic above or, optionally, with the enhancer protected by an enteric coating.
Inventors:
CHIYARANJITO BEERU
JIYOOJI BESUKIDO
NABUNITO SHIYAA
JIYATSUKU TOSUUNIAN
JIYOORU UNOUSUKI
JIYOOJI BESUKIDO
NABUNITO SHIYAA
JIYATSUKU TOSUUNIAN
JIYOORU UNOUSUKI
Application Number:
JP19110183A
Publication Date:
June 16, 1984
Filing Date:
October 14, 1983
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
C07D477/00; A61K9/36; A61K9/48; A61K9/62; A61K31/397; A61K31/40; A61K31/43; A61K31/535; A61K31/545; A61K47/14; A61K47/26; C07D499/46; C07D499/64; C07D499/68; C07D499/893; C07D499/897; (IPC1-7): A61K9/00; A61K31/40; A61K31/43; A61K31/535; A61K31/545; A61K47/00; C07D487/04; C07D499/46; C07D499/68
Attorney, Agent or Firm:
Heikichi Odashima