Title:
PHARMACEUTICAL COMPOSITIONS WITH PHOSPHONIUM ANTIMICROBIAL AGENTS
Document Type and Number:
Japanese Patent JP2016041773
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide pharmaceutical compositions with phosphonium antimicrobial agents.SOLUTION: The present invention is related to pharmaceutical compositions that include a phosphonium antimicrobial agent. In a preferred embodiment, the present invention relates to an otic, nasal or ophthalmic composition (e.g., an aqueous ophthalmic solution) that includes a phosphonium salt compound as an antimicrobial agent. The compositions typically possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements and/or similar preservative standards (e.g., EP and JP). The present invention is predicated upon the provision of a pharmaceutical composition that includes a phosphonium compound as an antimicrobial agent. Advantageously, it has been found that such compositions can be formulated to exhibit relatively high degrees of anti-microbial activity while also exhibiting relatively low toxicity. Such phosphonium compounds have been found to be particularly useful as antimicrobial agents in ophthalmic compositions such as contact lens disinfecting solutions and ophthalmic pharmaceutical compositions (i.e., ophthalmic compositions includes an ophthalmic therapeutic agent).SELECTED DRAWING: None
Inventors:
CHOWHAN MASOOD A
WESLEY WESHIN HAN
SCHNEIDER L WAYNE
WESLEY WESHIN HAN
SCHNEIDER L WAYNE
Application Number:
JP2016000274A
Publication Date:
March 31, 2016
Filing Date:
January 04, 2016
Export Citation:
Assignee:
ALCON RES LTD
International Classes:
A61K31/662; A61K9/08; A61P27/02; A61P27/04; A61P31/04
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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