Title:
PHARMACEUTICAL PREPARATION
Document Type and Number:
Japanese Patent JPH01104048
Kind Code:
A
Abstract:
PURPOSE: To provide a pharmaceutical preparation consisting of micelle dispersed with a heterocyclic compd. contg. a specific N-alkylated quat. nitrogen and a hydrophobic, pharmaceutically active material in a solvent, contg. the active material in stable form, and capable of being rapidly and perfectly released in the treating region.
CONSTITUTION: This compd. is pharmaceutical preparations consist of micelle in which a compd. represented by the formula (where X is NH or S; Y is N or CH; Q is N, C-CH3 or CH; R1 is H, OH, F or NH2; R2 is H, OH or NH2; (n) is 8-20, especially 15; Z- is an ion of Cl, Br, I, maleate, formate, acetate propionate, hydrosulfate malate fumarate salicylate, alginate, gluconate glucuronate, galacturonate, ethylsulfate or hydrogenphosphate), for example a 7-n-alkylimidazolium [4,5-d]-pyrimidine and a hydrophobic pharmaceutical active material are dispsed in the solvent at pH ≤7, and critical micelle forming concentration of the pharmaceutical preparation is within the range from 1.0×10-7 to 1.5×10-4 mol/liter. The compd. represented by the formula has strong antimicrobial and antimold effects.
Inventors:
HENRITSUHI HASUKO PARADEIISU
Application Number:
JP19899087A
Publication Date:
April 21, 1989
Filing Date:
August 06, 1987
Assignee:
PUETTER MEDICE CHEM PHARM
International Classes:
A61K9/10; A61K9/107; A61K9/127; A61K31/375; A61K31/395; A61K31/41; A61K31/415; A61K31/4184; A61K31/425; A61K31/426; A61K31/428; A61K31/44; A61K31/4418; A61K31/4425; A61K31/46; A61K31/47; A61K31/49; A61K31/496; A61K31/505; A61K31/52; A61K31/522; A61K31/53; A61K31/65; A61K31/66; A61K33/24; A61K33/28; A61K33/30; A61K33/42; A61K31/70; A61K45/08; A61K47/00; A61K47/18; A61K47/22; A61P17/00; A61P17/16; A61P31/04; A61P31/12; A61P35/00; A61P43/00; C07C67/00; C07C213/00; C07C217/08; C07D209/00; C07D213/00; C07D213/20; C07D213/30; C07D213/63; C07D213/65; C07D213/68; C07D213/69; C07D213/73; C07D213/79; C07D213/80; C07D213/81; C07D213/82; C07D215/10; C07D215/18; C07D231/00; C07D231/12; C07D231/18; C07D231/20; C07D231/28; C07D233/00; C07D233/54; C07D233/58; C07D235/00; C07D235/06; C07D239/00; C07D239/26; C07D239/30; C07D239/36; C07D239/46; C07D239/47; C07D239/54; C07D239/553; C07D241/00; C07D241/12; C07D241/18; C07D241/24; C07D249/08; C07D251/18; C07D251/70; C07D277/00; C07D277/22; C07D277/62; C07D307/62; C07D471/04; C07D473/00; C07D473/04; C07D473/06; C07D473/16; C07D473/18; C07D473/28; C07D473/30; C07D473/32; C07D473/34; C07D473/38; C07D473/40; C07D487/04; C07D521/00; C09K23/18; C09K23/32; C12N9/99; G01N33/52; G01N33/532; G01N33/543; G01N33/544; G01N33/58; (IPC1-7): A61K9/10; A61K31/375; A61K31/41; A61K31/46; A61K31/505; A61K31/65; A61K31/70; A61K31/71; A61K33/28; A61K47/00; B01F17/32; C07; C07C93/04; C07D213/20; C07D213/68; C07D213/79; C07D215/10; C07D231/12; C07D231/18; C07D233/58; C07D235/06; C07D239/26; C07D239/36; C07D239/47; C07D239/54; C07D239/55; C07D241/24; C07D277/22
Domestic Patent References:
Attorney, Agent or Firm:
Shintaro Nogawa
