Title:
アルギニンアミド類を含有する医薬製剤
Document Type and Number:
Japanese Patent JP3781308
Kind Code:
B2
Abstract:
A pharmaceutical preparation comprising a solution which contains as the active ingredient a substance selected from the group consisting of arginine amides represented by the general formula (I), salts thereof, and hydrates of both in a concentration of 1 to about 10mg/mL (with the proviso that the solution must contain at least water) and is packed in a container having a capacity of about 1 to about 20 mL: (I) [wherein R<1> is (2R, 4R)-4-alkyl-2-carboxypiperidino; and R<2> is phenyl or a residue of a fused polycyclic compound, and R<2> may have one or more substituents selected from among lower alkyl, lower alkoxy, and amino groups susbstituted with lower alkyl groups, with the provisos that the residue of a fused polycyclic compound bears a benzene ring and the benzene ring is bonded to the sulfonyl sulfur in the general formula (I) and fused with other rings including heterocycles and that the total number of ring-constituting carbon atoms of the residue is 7 to 14]. The pharmaceutical preparations and pharmaceutical compositions of the invention have advantages of high convenience and safety in medical service, good storage stability, and easy and simple producibility.
Inventors:
Kazuhiko Ozaki
Manami Hiramiya
Yoshizawa Katsuyoshi
Takashi Yamada
Hirokawa Takeshi
Koichi Sugawara
Katsunori Kurusu
Noboru Yamada
Kenichi Kajiwara
Manami Hiramiya
Yoshizawa Katsuyoshi
Takashi Yamada
Hirokawa Takeshi
Koichi Sugawara
Katsunori Kurusu
Noboru Yamada
Kenichi Kajiwara
Application Number:
JP2005503766A
Publication Date:
May 31, 2006
Filing Date:
March 19, 2004
Export Citation:
Assignee:
MITSUBISHI PHARMA CORPORATION
Towa Pharmaceutical Co., Ltd.
Towa Pharmaceutical Co., Ltd.
International Classes:
A61K31/4709; A61K9/00; A61K9/08; A61K31/4545; A61K47/10; A61K47/26; C07D401/12
Domestic Patent References:
| JP64031727A | ||||
| JP59219225A | ||||
| JP2003509350A | ||||
| JP2002523336A |
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes