Title:
置換アミドの製薬学的用途
Document Type and Number:
Japanese Patent JP2009514818
Kind Code:
A
Abstract:
The use of substituted amides for modulating the activity of 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11betaHSD1 and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
Inventors:
Henrixne, Andersen
Ergensen, Anchor Steen
Kilburn, John Paul
Campen, Gita Camila Tail Girl
Ebdorp, Seiren
Ergensen, Anchor Steen
Kilburn, John Paul
Campen, Gita Camila Tail Girl
Ebdorp, Seiren
Application Number:
JP2008537121A
Publication Date:
April 09, 2009
Filing Date:
November 01, 2006
Export Citation:
Assignee:
High Point Pharmaceuticals, Limited Liability Company
International Classes:
C07C237/42; A61K31/166; A61K31/18; A61K31/277; A61K31/403; A61K31/4174; A61K31/4178; A61K31/422; A61K31/427; A61K31/433; A61K31/439; A61K31/4439; A61K31/454; A61K31/47; A61K31/505; A61K31/506; A61K31/5377; A61K31/55; A61P1/08; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P3/14; A61P5/16; A61P5/40; A61P5/42; A61P5/50; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/06; A61P13/02; A61P13/12; A61P15/00; A61P15/10; A61P17/04; A61P17/14; A61P19/00; A61P19/08; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/06; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P27/02; A61P27/06; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P35/02; A61P37/02; A61P37/08; A61P41/00; C07C255/57; C07C275/28; C07C311/06; C07D209/02; C07D211/62; C07D215/04; C07D221/22; C07D223/14; C07D223/32; C07D233/34; C07D239/42; C07D277/20; C07D277/48; C07D285/10; C07D401/12; C07D403/10; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/10; C07D417/12; C07D491/08
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei