Title:
PHARMACOLOGICAL ACTIVE AMIDES, MANUFACTURE AND PHARMACOLOGICAL COMPOSITION
Document Type and Number:
Japanese Patent JPS625946
Kind Code:
A
Abstract:
Amides of formula: I in which A is V and W are H, halogen, alkyl (1-3C), alkoxy (1-3C), NO2 or CF3, Z is bound in the ortho or para position with respect to B and is phenyl, optionally substituted, thienyl or pyridyl, the chain X-(CH2)n-(CHR)m-CO-NR1R2 is bound in the ortho or para position with respect to B, R is H or alkyl (1-3C), R1 and R2 are alkyl (1-6C), cycloalkyl (3-6C), phenyl, phenylalkyl, cycloalkylalkyl, alkenyl (3-6C), R1 and R2 can also form, with the nitrogen atom to which they are attached, a pyrrolidine, piperidine, morpholine or thiomorpholine ring, X is >CH-R3, >N-R4, >SO, >SO2, >O or >S, R3 is H, alkyl (1-3C), R4 is alkyl (1-3C) m=0 or 1 and n=0, 1 or 2, provided that, if X is >SO, >SO2 or >N-R4, the sum m+n is equal to at least 1, that, when A and B are N and Z is in the para position with respect to B, X cannot denote the group >CH-R3 and that when A is CH, B is N, Z is in the ortho position with respect to B, X is an oxygen atom, and R is a hydrogen atom, the sum m+n is other than 1, and excluding 2-phenyl-4-quinolyl N,N-dimethylcarbamate, have useful pharmacological activity, e.g. as anxiolytics, anticonvulsants and antiangina agents.
Inventors:
JIIZASU BENABIDESU
MARII KURISUCHIINU DEYUBURUUKU
JIERAARU RU FUYUURU
KURISUCHIYAN RUNOO
MARII KURISUCHIINU DEYUBURUUKU
JIERAARU RU FUYUURU
KURISUCHIYAN RUNOO
Application Number:
JP12387286A
Publication Date:
January 12, 1987
Filing Date:
May 30, 1986
Export Citation:
Assignee:
RHONE POULENC SANTE
International Classes:
A61K31/43; A61K31/47; A61K31/4709; A61K31/472; A61K31/495; A61K31/505; A61K31/517; A61K31/535; A61K31/54; A61P9/08; A61P9/10; A61P25/20; A61P25/22; A61P37/00; C07C67/00; C07C67/307; C07C231/00; C07C231/02; C07C231/12; C07C233/04; C07C233/06; C07C235/04; C07C233/11; C07C235/32; C07C235/34; C07C239/00; C07C269/00; C07C313/00; C07C317/44; C07C323/32; C07D213/22; C07D215/12; C07D215/14; C07D215/20; C07D215/22; C07D215/227; C07D215/233; C07D215/36; C07D215/38; C07D215/42; C07D215/48; C07D217/14; C07D217/16; C07D217/22; C07D217/24; C07D217/26; C07D239/74; C07D239/82; C07D239/88; C07D239/91; C07D239/96; C07D333/00; C07D401/04; C07D401/12; C07D409/04; C07D409/12; C07D413/12; (IPC1-7): A61K31/47; A61K31/505; C07/; C07C103/50; C07C103/76; C07C125/06; C07C147/06; C07C147/14; C07D213/00; C07D215/00; C07D215/14; C07D215/20; C07D215/36; C07D215/38; C07D217/16; C07D217/22; C07D217/24; C07D239/00; C07D239/74; C07D401/04; C07D409/04
Attorney, Agent or Firm:
Heikichi Odashima
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