PHARMACOLOGICALLY ACTIVE COMPOUND

Japanese Patent JP2002322180

A

To provide pharmacologically active compounds.

The present invention provides the compounds represented by general formula (I) [wherein, Q is represented by general formulas (2)-(5)]. These compounds inhibit cyclic guanosine-3',5'-monophosphate phosphodiesterases (cGMP PDE). It is noteworthy that they inhibit V-type cyclic guanosine-3', 5'-monophosphate phosphodiesterase strongly and selectively. Therefore, they are useful in various therapeutic fields. Concretely, the compounds of the present invention are useful for prophylactic or therapeutic treatment to the sexual dysfunction of mammals.

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BARBER CHRISTOPHER GORDON
MAW GRAHAM NIGEL

JP2002068015A

November 08, 2002

March 13, 2002

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PFIZER

A61K31/444; A61K31/496; A61K31/4985; A61K31/519; A61K31/55; A61P1/00; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/08; A61P13/10; A61P15/00; A61P15/10; A61P17/06; A61P17/14; A61P25/00; A61P25/28; A61P27/06; A61P27/16; A61P35/00; A61P35/04; A61P43/00; C07D213/80; C07D471/04; C07D471/14; C07D487/04; C07D487/14; (IPC1-7): C07D487/04; A61K31/444; A61K31/496; A61K31/4985; A61K31/519; A61K31/55; A61P1/00; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/08; A61P13/10; A61P15/00; A61P15/10; A61P17/06; A61P17/14; A61P25/00; A61P25/28; A61P27/06; A61P27/16; A61P35/00; A61P35/04; A61P43/00; C07D471/14; C07D487/14

Kazuo Shamoto (5 outside)

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