PHARMACOLOGICALLY ACTIVE SUBSTITUTED 33AMINOOSYDNONEIMINE* ITS MANUFACTURE AND PHARMACEUTIC BLEND CONTAINING IT

Title:

PHARMACOLOGICALLY ACTIVE SUBSTITUTED 33AMINOOSYDNONEIMINE* ITS MANUFACTURE AND PHARMACEUTIC BLEND CONTAINING IT

Document Type and Number:

Japanese Patent JPS5625174

Kind Code:

A

Abstract:

Physiologically-acceptable 3-aminosydnonimines of the formula (I) and their pharmacologically-acceptable acid-addition salts, when formulated into medicament dosage forms, are useful for reducing systemic blood pressure, pulmonary artery pressure and left ventricular end diastolic pressure when orally administered to patients in need of such pressure reduction. These compounds are prepared by cyclizing a compound which, in its free-base state, is of the formula (II) to a corresponding product which, in its free-base state, is of the formula (Ia) and, when R2 is other than -H, acylating that product.

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Inventors:

KARURU SHIEENAFUINGERU
RUUDEI BAIERURE
RORUFU EEBERUHARUTO NITSUTSU
PIERO AA MARUTORAANA
FUORUKERU FUIITORERU

Application Number:

JP10140380A

Publication Date:

March 10, 1981

Filing Date:

July 25, 1980

Export Citation:

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Assignee:

CASSELLA FARBWERKE MAINKUR AG

International Classes:

A61K31/41; A61K31/4245; A61K31/425; A61K31/455; A61K31/495; C07D413/04; A61K31/496; A61K31/50; A61K31/54; A61P9/00; A61P9/12; C07D271/04; C07D295/22; C07D295/28; C07D413/06; C07D417/12; C07D417/04; (IPC1-7): A61K31/425; A61K31/495; A61K31/54; C07D271/04; C07D417/04

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