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Title:
PHENOXY DERIVATIVE
Document Type and Number:
Japanese Patent JPH04217646
Kind Code:
A
Abstract:

PURPOSE: To provide a new phenoxy derivative which is a synthetic intermediate for a pyrimidone derivative useful as a treating agent for peptic ulcer having gastric acid secretion suppressing action as well as digestive tract mucosa protecting action.

CONSTITUTION: A compound of formula I [Y is group of formula II (R1 and R2 are 1-6C lower alkyl) or formula III (n is 1-3)], e.g. 4-[3-(1,3-dioxolan-2-yl) phenoxy-cis-2-butenylamine. The compound can be produced by reacting a phthalimide derivative of formula IV with hydrazine hydrate in a solvent (e.g. ethanol) at room temperature. A treating agent for peptic ulcer can be prepared in high efficiency by reacting the compound of formula I with a pyrimidone compound and reacting the product with piperidine e.g. under reducing condition.


Inventors:
NOHARA FUJIO
Application Number:
JP2421191A
Publication Date:
August 07, 1992
Filing Date:
February 19, 1991
Export Citation:
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Assignee:
IKEDA MOHANDO CO
International Classes:
C07C217/46; C07D239/47; C07D317/18; C07D325/00; (IPC1-7): C07C217/46; C07D239/47; C07D317/18; C07D325/00
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)