To obtain the subject new phenoxyacetic acid and phenoxymethyltetrazole derivative each functioning as an antagonist in the interaction between MDM2 and p 53, inducing the growth of an active p 53 in cells, and enabling a p 53 protein to accelerate an apoptosis in cancerous cells.
This compound is of formula I [A is e.g. -COOH, -COO-, CN or an 1-4C alkyl; (p) is 0, 1 or 2; R1 and R2 are each e.g. H or an 1-8C alkyl; R4 is e.g. Cl, Br, I, F, an 1-8C alkyl or a hydroxy; (n) is an integer of 1 to 4; (m) is 0 or 1; and B is e.g. an 1-10C alkyl or -CO-C(R3)=CH-R (R is e.g. H; and R3 is H or 1-8C alkyl)], e.g. a compound of formula II. A compound of formula I wherein (m) is 0 and B is e.g. an 1-10C alkyl or -COCH3 can be prepared by beginning with the use of an intermediary of formula III [B' is e.g. an 1-10C alkyl, -COCH3 or -CO-C(R3)-CH-R] and subsequently using an appropriate acid ester or nitrile.
SILKE HANSEN
BRIGITTE CALZA
MENTA ERNESTO
RALF SCHUMACHER
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