Title:
IP受容体アンタゴニストとしてのフェニルまたはヘテロアリールアミノアルカン誘導体
Document Type and Number:
Japanese Patent JP2006514110
Kind Code:
A
Abstract:
The present invention relates to phenyl or heteroaryl amino alkane derivatives of formula (I) in which the groups Q1-Q4, Ar, and R1-R7 are as defined in the specification and claims. These materials are useful as active ingredients of pharmaceutical preparations. The phenyl or heteroaryl amino alkanes of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorders as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since these diseases also are alleviated by treatment with an IP receptor antagonist. The application claims the compounds, pharmaceutical compositions containing them, and methods of treatment using them.
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Inventors:
Toshiki Murata
Umeda Masaomi
Satoru Yoshikawa
Klaus Waberns
Jung Gupta
Osamu Sakurai
Umeda Masaomi
Satoru Yoshikawa
Klaus Waberns
Jung Gupta
Osamu Sakurai
Application Number:
JP2005506646A
Publication Date:
April 27, 2006
Filing Date:
October 29, 2003
Export Citation:
Assignee:
Bayer HealthCare AG
International Classes:
C07C229/14; A61K31/192; A61K31/40; A61K31/415; A61K31/42; A61K31/426; A61K31/44; A61K31/4965; A61K31/505; A61K31/506; A61K31/53; A61K31/5377; A61P1/02; A61P7/04; A61P7/12; A61P9/02; A61P11/06; A61P13/02; A61P13/08; A61P13/10; A61P15/00; A61P15/08; A61P19/00; A61P25/04; A61P25/06; A61P29/00; A61P37/08; A61P43/00; C07C229/36; C07D207/325; C07D213/30; C07D213/38; C07D213/64; C07D213/74; C07D231/38; C07D239/42; C07D241/20; C07D251/14; C07D261/14; C07D277/20; C07D277/42; C07D401/04; C07D401/10; C07D401/12; C07D401/14; C07D403/10; C07D403/12; C07D405/10; C07B61/00
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Yasuo Shibata
Mitsutaka Iwasaki
Shoji Nakajima
Yasuo Shibata