PHENYL HETEROCYCLIC RING AS CYCLOOXYGENASE-2 INHIBITOR

Title:

PHENYL HETEROCYCLIC RING AS CYCLOOXYGENASE-2 INHIBITOR

Document Type and Number:

Japanese Patent JP3720634

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To obtain a new compound useful in pharmaceutical compositions for treating inflammatory diseases sensitive to the therapies using nonsteroidal anti-inflammatory agents.
SOLUTION: This new compound is shown by formula I [X-Y-Z is such as to be CH2CH2CH2, C(O)CH2CH2, S-N=CH, or the like when side (b) is a double bond and side (a) and side (c) are each a single bond, =N-S-CH=, =N-O-CH=, =N-S-N=, or the like when side (a) and side (c) are each a double bond and side (b) is a single bond; R1 is S(O)2CH3, S(O)2NHC(O)CF3, P(O)(CH3)OH, or the like; R2 is a 1-6C alkyl, 3-7C cycloalkyl, trisubstituted phenyl or the like], e.g. 3-[4-(aminosulfonyl)phenyl]-2-(4-fluorophenyl)-5-(2- hydroxy-2-propyl)thiophene. The compound of formula I is obtained, for example, by using a ketone of formula II (Ra is SMe or the like) as starting material to form a compound of formula III (R4 is H or the like).

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Inventors:

Eve Douchiam
Jack Eve Goushiya
Pepiboon plasmite
Eve Leblanc
The Oin Wang
Surge leger
Michael Zarien

Application Number:

JP17467899A

Publication Date:

November 30, 2005

Filing Date:

June 09, 1994

Export Citation:

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Assignee:

Merck Frost Canada and Company

International Classes:

A61K31/00; A61K31/10; A61K31/12; A61K31/122; A61K31/341; A61K31/351; A61K31/365; A61K31/38; A61K31/381; A61K31/4015; A61K31/426; A61P1/00; A61P1/02; A61P1/04; A61P7/04; A61P11/06; A61P15/00; A61P17/02; A61P19/00; A61P19/02; A61P21/00; A61P25/28; A61P29/00; A61P31/12; A61P31/16; A61P35/00; A61P43/00; C07C311/29; C07C311/46; C07C311/49; C07C317/24; C07D207/26; C07D207/444; C07D275/02; C07D277/02; C07D277/26; C07D307/33; C07D307/38; C07D307/58; C07D309/32; C07D333/18; C07D333/38; C07D333/40; C07D405/04; (IPC1-7): C07C317/24; A61K31/12; A61K31/365; A61K31/38; A61P29/00; C07D307/58; C07D333/18; C07D333/40

Domestic Patent References:

JP8510718A
JP314569A
JP58159489A

Attorney, Agent or Firm:

Yoshio Kawaguchi

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