To provide a compound having excellent VLA-4 inhibitory activity.
This phenylalanine derivative is represented by general formula (1) [wherein R1 represents a lower alkyl group, a 3-10C cycloalkyl group, a heterocyclic group, or a 6-10C aromatic hydrocarbon group; Z represents a phenyl group, benzoylamino group, pyridylcarbonylamino group, aralkyloxy group, morpholine-N-carboxy group, or phthalimido-N-yl group, R2 represents a hydrogen atom or a lower alkyl group; n represents a number of 0 or 1; and when n is 0, Y represents NOR3 (wherein R3 represents a hydrogen atom, methyl group, or phenyl group), CCl2, CHCL, C(CL)CH3, C(CH3)OCH3, CHCH3, CHph, etc.; when n is 1, Y represents NOR3 (wherein R3 represents the same as before); A represents a phenyl group, B represents a hydrogen atom, or a lower alkyl group, or A and B may bond to form a cyclopentane ring, cyclohexane ring, or oxane ring, or A and R1 may bond to form a cyclopentane ring, or cyclohexane ring], and its salts are also included in the invention.
OKAMOTO KOJI
IWABUCHI TAKEYUKI
INOUE TSUTOMU
NAKANO HIROYUKI
ISHIKAWA TOMOHIKO
KAWASAKI NOBUHIDE
KATO MASUMI
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Asano Yasutaka
Hiromi Matoba
Masaki Murata
Hiroto Yamamoto
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