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Document Type and Number:
Japanese Patent JP03261752
Kind Code:

NEW MATERIAL:A compound shown by formula I {A is NHCO, O, NHSO2, CH2, etc. ; W is 1-13C alkyl, phenylene, etc.; R1 is H, 1-4C alkyl, COOH, 4- to 7-membered monocyclic hetero-ring, etc.; A, W and R1 are bonded to form group shown by formula II, formula III, etc.; Y is ethylene or vinylene; D is Z-B [Z is 3-11C alkylene or 3-11C alkenylene; H is group shown by formula IV (R3 is H, halogen, 1-8C alkyl, etc.; n is 1-3] or group shown by formula V (R4 is 1-7C alkylene; R5 is 1-12C alkyl, phenethyl, etc.)} or a salt thereof.

EXAMPLE: 3-[1-[6-(4-Methoxyphenyl)hexa-5E-enyl]oxy-4-(5-oxo-5- morpholinopentanamido)benzen-2-yl]propionic acid.

USE: A leukotriene B4 antagonist.

PREPARATION: For example, a compound shown by formula VI is subjected to ester bond hydrolysis to give a corresponding compound shown by formula I.

Konno, Yoshitoshi
Nakae, Takahiko
Hamanaka, Nobuyuki
Application Number:
Publication Date:
November 21, 1991
Filing Date:
May 15, 1990
Export Citation:
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International Classes:
A61K31/19; A61K31/165; A61K31/195; A61K31/215; A61K31/40; A61K31/4015; A61K31/403; A61K31/4035; A61K31/404; A61K31/425; A61K31/426; A61K31/535; A61K31/5375; A61K31/54; A61P29/00; A61P37/08; A61P43/00; C07C51/09; C07C59/52; C07C59/64; C07C59/66; C07C59/68; C07C59/72; C07C59/90; C07C69/734; C07C205/34; C07C205/56; C07C233/47; C07C233/54; C07C233/55; C07C233/81; C07C233/87; C07C235/06; C07C235/16; C07C235/20; C07C235/32; C07C235/34; C07C235/38; C07C235/42; C07C235/56; C07C235/74; C07C235/78; C07C311/08; C07C311/13; C07C311/21; C07C311/32; C07C311/37; C07C311/48; C07C311/51; C07C323/19; C07C405/00; C07D207/27; C07D209/08; C07D209/48; C07D215/08; C07D217/06; C07D219/02; C07D275/02; C07D275/03; C07D277/20; C07D277/42; C07D277/44; C07D277/46; C07D279/02; C07D295/10; C07D295/18; C07D295/185; C07D333/16; C12N9/99; C07D207/26; (IPC1-7): A61K31/19; A61K31/215; A61K31/40; A61K31/425; A61K31/54; C07C59/66; C07C59/90; C07C233/54; C07C233/81; C07C233/87; C07C235/06; C07C235/16; C07C235/20; C07C235/34; C07C235/56; C07C235/74; C07C311/08; C07C311/13; C07C311/48; C07C311/51; C07C323/19; C07D207/27; C07D209/48; C07D275/03; C07D277/46; C07D279/02; C07D295/10