NEW MATERIAL:A phenylcyclohexane derivative of formula I(R1 is H, hydroxyl group or alkoxyl; R2 is H, aminoalkyl, alkoxylcarbonylalkyl or aminocarbonylalkyl; R3 is oxo, hydroxyl group, alkylcarbonylamino, alkycarbonyloxy, aminoalkylcarbonyloxy, etc.; R4 is H, aminoalkyl, morpholino or morpholinoalkyl; however, R3 and R4 are not H at the same time).
EXAMPLE: 2-Ethoxycarbonylmethyl-6-morpholino-2-phenylcyclohexanone.
USE: Useful as a medicine having inhibitory action on blood platelet aggregation, inhibitory action on contraction of extirpated intestines and anti-inflammatory and analgesic actions.
PROCESS: Either one of R2 or R4 or both are introduced into a phenylcyclohexane of formula II as a starting raw material by the well-known method to give the aimed compound of formulaI (R3 is oxo group).
HORI MIKIO
TATSUOKA TOSHIO
OKITSU MITSUTO
IMAO KAYOKO
MORITA MINORU
JPS51138680A | 1976-11-30 | |||
JPS50157342A | 1975-12-19 |
US4150135A | 1979-04-17 |