To obtain a phenylene derivative having both an antileucotriene action and an antihistamine action and useful as an asthma-preventing and treating agent, etc.
This phenylene derivative is represented by formula I {R1 is H, a halogen; A is CH=CH, CH=N, O, S, etc.; W is CH=CH, CH2O; X is CH2O, CH2S, COO, etc.; Y is a group of formula II [R4 is H, a lower alkyl; R5 is H, a lower alkyl; Z1 is O atom, S atom; B1 is CH=CR9 (R9 is H, cyano, etc.), etc.], a group of formula III, etc.} or its salt, e.g. 3-cyano-6-[3-(2- quinolylmethoxy)benzyloxy]-1,2-dihyroxyquinolin-2-one. The compound of formula I is obtained from a compound of formula IV as a starting raw material through several processes. A medicine containing the compound of formula I as an active ingredient gives effects on the preventions and treatments of asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, etc.
MINJIYAN ZANGU
ONOKI KAZUHIRO
TAMURA MASAHIRO
TAIMA TSUTOMU
WADA YASUSHI
