NEW MATERIAL:A phenylmethylbenzoquinone derivative of formula I [R1, R2 and R3 are independently H, methyl or methoxy; A is ethylene or vinylene; n is 0 or 1; R4 is H, hydroxymethyl or (esterified or amidated) carboxyl].
EXAMPLE: 3-[3-(2,5-Benzoquinonylmethyl)phenyl]acrylic acid ethyl ester.
USE: It has brain-protective action in cerebral anoxia and is useful as an ameliorating and remedying agent for intracerebral organic disorder and pathergasia.
PREPARATION: The compound of formula I can be produced e.g. by reacting an aldehyde of formula II with a Grignard reagent of a halide of formula III [X is Br or Cl; R7 is group of formula IV or -CH(OC2H5)2], treating the product with an acid, reacting with Wittig reagent of triethyl phosphonoacetate and subjecting the product to reaction with acetic anhydride, catalytic reduction, hydrolysis, etc.
SUZUKI KENJI
SATO FUMIO
MIYANO SEIJI
SUMOTO KUNIHIRO
US3576016A | 1971-04-20 |
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