Title:
フェニルピロリジンエーテル系タキキニン受容体拮抗薬
Document Type and Number:
Japanese Patent JP2007507504
Kind Code:
A
Abstract:
The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, depression, and anxiety.
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Inventors:
Debita, Robert Jay
Mills, Thunder Gi
Young, Jyonathan Earl
Lin, Peter
Mills, Thunder Gi
Young, Jyonathan Earl
Lin, Peter
Application Number:
JP2006533976A
Publication Date:
March 29, 2007
Filing Date:
September 24, 2004
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D207/08; A61K31/40; A61K31/4015; A61K31/4025; A61K31/404; A61K31/41; A61K31/4155; A61K31/416; A61K31/4178; A61K31/4184; A61K31/4192; A61K31/4196; A61K31/422; A61K31/423; A61K31/427; A61K31/428; A61K31/433; A61K31/437; A61K31/4375; A61K31/4439; A61K31/454; A61K31/455; A61K31/496; A61K31/497; A61K31/4985; A61K31/501; A61K31/502; A61K31/506; A61K31/517; A61K31/519; A61K31/5375; A61K31/5377; A61P1/00; A61P1/04; A61P1/06; A61P7/10; A61P9/00; A61P9/10; A61P11/02; A61P11/06; A61P13/00; A61P17/00; A61P17/04; A61P19/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P27/02; A61P29/00; A61P37/02; A61P43/00; C07D207/04; C07D207/12; C07D207/14; C07D207/28; C07D207/38; C07D401/04; C07D401/06; C07D401/14; C07D403/04; C07D403/06; C07D403/10; C07D403/12; C07D405/04; C07D405/06; C07D409/06; C07D413/02; C07D413/06; C07D417/06; C07D417/12; C07D471/04; C07D487/04; C07D513/04; A61K
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura