置換フェノールを含むヒドロキシ酸エステルのリン酸エステル化合物、その製造方法及びそれを用いた中枢抑制薬

Japanese Patent JP5650320

B2

Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y = C 1-4 straight carbon chain, M 1 and/or M 2 = H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2, 6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.

WO/2001/094356	AQUEOUS COMPOSITIONS CONTAINING ALKALI METAL SALTS OF PARTIAL ALKYL ESTERS OF PHOSPHORIC ACID, METHOD FOR STABILIZATION AND TEXTILE OILS
WO/1987/000172	ASCORBATE 2-POLYPHOSPHATE ESTERS AND METHOD OF MAKING SAME
JP2003520760	INDUSTRIAL APPLICABILITY [Title of Invention] Use for manufacturing pharmaceutical preparations for treatment and preventive treatment of infectious diseases, or as fungicides, fungicides or herbicides in plants

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JP2013515653A

January 07, 2015

October 13, 2010

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四川大学華西医院
宜昌人福薬業有限責任公司

C07F9/09; A61K31/661; A61P23/00; A61P25/20

Katsuhiro Yoshimura

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