Title:
ホスホジエステラーゼ(PDE)7のプリン阻害剤
Document Type and Number:
Japanese Patent JP2005500295
Kind Code:
A
Abstract:
Pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors are provided which are useful in treating T-cell mediated diseases, said inhibitors include: (i) 2-[[4-[[[4-(Aminosulfonyl)phenyl]methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid, ethyl ester; and 4-Methyl-2-[[4-[[[4-(methylsulfonyl)phenyl]methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]amino]-5-thiazolecarboxylic acid, ethyl ester; or (ii) an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt of (i).
Inventors:
Wayne Baccaro
Jax Wy Robage
Katerina Lefferis
William Jay Pitts
Joseph Barbosa
Jax Wy Robage
Katerina Lefferis
William Jay Pitts
Joseph Barbosa
Application Number:
JP2003504903A
Publication Date:
January 06, 2005
Filing Date:
June 17, 2002
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/00; A61K31/505; A61K31/506; A61K31/513; A61K31/517; A61K31/519; A61K31/52; A61K31/522; A61K31/5377; A61K31/551; A61K31/56; A61K31/573; A61K45/00; A61P1/00; A61P1/04; A61P3/10; A61P5/14; A61P9/08; A61P9/10; C07D239/95; A61P11/00; A61P11/04; A61P11/06; A61P17/04; A61P17/06; A61P17/14; A61P19/00; A61P19/02; A61P21/04; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C07D401/12; C07D403/12; C07D417/12; C07D417/14; C07D471/04; C07D473/00; C07D473/16; C07D487/04; C07D491/10; C07D498/10; (IPC1-7): C07D473/16; A61K31/52; A61K31/5377; A61K31/551; A61K31/56; A61K45/00; A61P1/00; A61P3/10; A61P9/08; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P43/00
Attorney, Agent or Firm:
Kyousei Tamura
Toshio Ueda
Nagatoshi Shinagawa
Toshio Ueda
Nagatoshi Shinagawa