Title:
ホスホイノシチド3-キナーゼ阻害剤化合物及び使用方法
Document Type and Number:
Japanese Patent JP5284977
Kind Code:
B2
Abstract:
Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R 3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Inventors:
Bayliss, Tracy
Chuckowry, Irina
Volks, Adrian
Oxenford, Surrey
Wan, Nan, Qi
Castanade, jjet
Goldsmith, Richard
Jansner, Gunsner
Tim Heflon
Mathieu, Simon
Oliven, Alan
Steven, Stephen
Sutherlin, Daniel, Pea.
Ju, Bin-Yang
Chuckowry, Irina
Volks, Adrian
Oxenford, Surrey
Wan, Nan, Qi
Castanade, jjet
Goldsmith, Richard
Jansner, Gunsner
Tim Heflon
Mathieu, Simon
Oliven, Alan
Steven, Stephen
Sutherlin, Daniel, Pea.
Ju, Bin-Yang
Application Number:
JP2009540459A
Publication Date:
September 11, 2013
Filing Date:
December 05, 2007
Export Citation:
Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
Genentech, Incorporated
Genentech, Incorporated
International Classes:
C07D491/048; A61K31/5377; A61K45/00; A61P1/16; A61P3/10; A61P5/00; A61P7/02; A61P9/00; A61P9/10; A61P17/02; A61P17/06; A61P19/00; A61P25/00; A61P25/06; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D495/04
Domestic Patent References:
| JP2009538825A |
Foreign References:
| WO2006046040A1 |
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori