Title:
PHOSPHOLIPASE A2 INHIBITING COMPOSITION AND ITS USE
Document Type and Number:
Japanese Patent JPH0270703
Kind Code:
A
Abstract:
PURPOSE: To inhibit cell secretion, eicosanoide production, and film PLA2 activity in natural cells without inhibiting cell survivability by containing a specific cell-permeable enzyme phospholipase A2(PLA2) inhibitor part.
CONSTITUTION: A cell-permeable PLA2 inhibitor part (e.g. phosphatidyl- ethanolamine) except] phospatidylseline, which is indirectly coupled to a dextrane hydrazide via a divalent dodecanedioyl group, is covalently bonded directly or indirectly to a physiologically acceptable carrier part (e.g. decomposed gelatin polypeptide crosslinked by an urea bridge) that is effective to inhibit cell internalization of a cell-permeable enzyme pospholipase A2(PLA2) inhibitor part, to obtain a PLA2 inhibitor composition.
Inventors:
SAURU IEDOGAA
ARIE DAGAN
ARIE DAGAN
Application Number:
JP26701388A
Publication Date:
March 09, 1990
Filing Date:
October 21, 1988
Export Citation:
Assignee:
YISSUM RES DEV CO
International Classes:
A61K31/00; A61K31/215; A61K31/685; A61K31/74; A61K47/00; A61K47/30; A61K47/48; A61P7/02; A61P29/00; A61P43/00; C07F9/10; C07K14/00; C12N9/99; C07K14/81; C08B31/00; C08B37/02; C08B37/04; (IPC1-7): A61K31/00; A61K31/215; A61K31/685; A61K31/74; A61K47/30; C07F9/10; C07K15/12; C07K15/24; C08B31/00; C08B37/02; C08B37/04; C12N9/99
Attorney, Agent or Firm:
Akaoka Michio
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