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Title:
PHOSPHOLIPID DERIVATIVE, ITS PREPARATION AND ANTITUMOR AGENT CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPS5942394
Kind Code:
A
Abstract:

NEW MATERIAL:The compound of formula I [R1 is alkyl(thio), alkoxy, or alkylsulfonyl; R2 is H, OH, alkoxy, lower alkanoyloxy, etc.; R3 is (protected) OH; R4 is lower alkoxy or lower cycloaliphatic-oxy substituted with ≥2 (protected) OH groups; n is 0 or 1] and its salt.

EXAMPLE: DL-2-O-methyl-3-O-octadecyl-glyceryl 2-(DL-myoinosityl) phosphate.

USE: Antitumor agent.

PROCESS: The compound of formula III can be prepared e.g. by reacting the compound (salt) of formula II (R2a is H, alkoxy, lower alkanoyloxy, etc.; R3a is protected OH; X is halogen or silver-oxy) with the compound (salt of formula y- R4a (R4a is lower alkyl or lower cycloaliphatic-oxy substituted with ≥2 protected OH groups; when X is halogen, Y is OH, and when X is silver-oxy, Y is halogen).


Inventors:
Terachi, Tsutomu
Todo, Eishiro
Shimazaki, Norihiko
Oku, Teruo
Namiki, Takayuki
Application Number:
JP1983000139709
Publication Date:
March 08, 1984
Filing Date:
July 29, 1983
Export Citation:
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Assignee:
FUJISAWA PHARMACEUT CO LTD
International Classes:
A01N57/12; A61K31/66; A61P35/00; C07D309/12; C07F9/09; C07F9/10; C07F9/117; C07H9/04; C07H11/04; C07H13/04; C07H13/08; (IPC1-7): A61K31/66; C07F9/10