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Title:
PHOSPHOLIPID AND USE THEREOF
Document Type and Number:
Japanese Patent JPS6354386
Kind Code:
A
Abstract:

NEW MATERIAL:A compound expressed by formula I (m represents a positive integer).

EXAMPLE: 2-Acetoxy-3-(7-carboxyheptyloxy) propyl 2-trimethylammonioethyl phosphate.

USE: An antigen useful for preparation of an antibody specific to a platelet activating factor (PAF), which antibody is useful for an assay of PAF.

PREPARATION: A compound expressed by formula II (x represents hydroxyl- protecting group; Ph represents phenyl) is reacted with a compound expressed by the formula Z-(CH2)m Y (Z represents Br, I, etc.; Y represents cyano, 2- oxazolinyl, etc.), followed by deprotection of the product and esterification of group Y thereof. Then the produced compound expressed by formula III (R represents 1W4C alkyl) is reacted with a compound expressed by formula IV, and the product is reacted successively with water and triethylamine. The obtained compound expressed by formula V (Me represents methyl) is then successively subjected to hydrolysis, hydrogenolysis and acetylation.


Inventors:
AONO TETSUYA
NISHIKAWA KOHEI
Application Number:
JP20033586A
Publication Date:
March 08, 1988
Filing Date:
August 26, 1986
Export Citation:
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Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
C07F9/10; A61K39/395; (IPC1-7): A61K39/395; C07F9/10
Attorney, Agent or Firm:
Hiroshi Iwata