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Title:
PHTHALAZONE DERIVATIVE
Document Type and Number:
Japanese Patent JPS5976069
Kind Code:
A
Abstract:

NEW MATERIAL:The phthalazone derivative of formula (R and R' are 1W12C alkyl).

EXAMPLE: 4-Acetoxymethyl -2-acetyl -7-ethoxycarbonyl-6,8-dimethyl-1( 2H )-phthalazone.

USE: Useful as a bioprecursor of phthalazinol which is a remedy effective to the subjective symptoms of the sequela of cerebrovascular disorder, the psychic symptoms, the central pain, etc. Although the compound has no physiological activity, it is converted to phthalazinol in the living body, and furthermore, it has higher solubility, absorbability to the body, and metabolic properties than phthalazinol.

PROCESS: The compound of formula can be prepared, e.g. by using phthalazinol (known compound) as a starting compound, and reacting with a 1W12C carboxylic acid anhydride, halide, etc. preferably in a solvent such as pyridine.


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Inventors:
ISHIKAWA MASAYUKI
MORIGUCHI SOYAO
WATANABE MARIKO
SAKAI YASUYUKI
SHIRAI HIDEO
SAITOU MORIHIRO
EBISAWA HISASHI
Application Number:
JP18600082A
Publication Date:
April 28, 1984
Filing Date:
October 25, 1982
Export Citation:
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Assignee:
SHOWA DENKO KK
International Classes:
C07D237/32; A61K31/50; A61K31/502; A61P7/02; A61P9/10; (IPC1-7): A61K31/50; C07D237/32
Attorney, Agent or Firm:
Kikuchi Seiichi



 
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