NEW MATERIAL:A quinone of formula I [α-β part is saturated or double bond; R is methyl or methoxy, or two Rs are bonded into CH=CH-CH=CH; R1 is carboxyl, aldehyde, (CH2)mOH, etc.; m is an integer 1W3; R2 is H or hydroxyl group; n is an integer 0W9].
USE: Useful for prevention and treatment of diseases, e.g. hypertension, cardiac insufficiency, asthma, cerebral apoplexy, etc., as a hypotensive, heart-treating or bronch odilator, etc., having a pharmacological action, e.g., a stabilizing action on biomembranes of mammals, e.g. rats or mice, an electron transport activity of mitochondrias, a hypotensive activity, a preventing action on cardiomegaly, a relaxing action on tracheal muscles, an improving action on the cerebral circulation, a protecting action against cerebral ischemia, etc.
PROCESS: A compound of formula II (X and Y are hydroxyl or amino groups, or one of X and Y is H) is oxidized, to give a compound of formula I.
TERAO SHINJI
KAWADA MITSURU
SHIRAISHI MITSURU
| JPS5095244A | 1975-07-29 | |||
| JPS5024245A | 1975-03-15 | |||
| JPS5110229A | 1976-01-27 | |||
| JPS4738429A |