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Title:
PHYSIOLOGICALLY ACTIVE SUBSTANCE M4529 AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPS6483090
Kind Code:
A
Abstract:

NEW MATERIAL:Physiologically active substance M4529 having the following physical and chemical properties, its hydrate and their salts. Nature, acidic substance; elemental analysis (%) (as C12H10N2O8.2H2O), C 42.04, H 3.97, N 8.02; molecular formula, C12H10N2O8; color reactions, positive to KMnO4 bleaching reaction and iodine reaction and negative to FeCl3 reaction and ninhydrin reaction; etc.

USE: Remedy for cataract, retinopathy, neurosis, rhinitis, etc., which are complicates of diabetes. It has activity to inhibit aldose reductase.

PREPARATION: A microbial strain belonging to genus Coniochaeta and capable of producing physiologically active substance M4529 [e.g. Coniochaeta ellipsoidea M4529 (FERM P-9505)] is cultured in a medium preferably at pH 3.0W9.5 for 2W9 days.


Inventors:
Yaginuma, Satoshi
Asahi, Teru
Takada, Masaki
Mizuno, Kimio
Application Number:
JP1987000240364
Publication Date:
March 28, 1989
Filing Date:
September 25, 1987
Export Citation:
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Assignee:
TOYO JOZO CO LTD
International Classes:
A61K35/66; A61K36/06; A61P3/08; A61P3/10; A61P43/00; C07G11/00; C12P1/02; C12R1/645; (IPC1-7): A61K35/66; C07G11/00; C12P1/02