Title:
PHYSIOLOGICALLY ACTIVE SUBSTANCE TAN-1515, PRODUCTION THEREOF AND ITS USE
Document Type and Number:
Japanese Patent JP2979271
Kind Code:
B2
Abstract:
PURPOSE: To obtain the new title substance useful as antiphlogistics because of phospholipase A2 inhibiting activity and useful as a synthetic intermediate for new derivative.
CONSTITUTION: A physiologically active substance TAN-1515 having the following properties: Appearance, colorless crystal; melting point, 102-104°C; molecular formula, C32H46O7; elementary analysis, C 70.82 H 8.54 (calculated value), C 70.99 H 8.91 (measured value); color reaction, positive to Barton reaction, iodine reaction, etc., and negative to ninhydrin reaction and Dragendorff reaction; classification of acidic, neutral or basic, acidic. The compound 12 is obtained by culturing a microorganism [e.g. Acremonium sp. FL-175559 strain (FERM BP-3487)] belonging to Acremonium and capable of producing a compound expressed by the formula and purifying the cultured mixture. Furthermore, temperature in the meddle period of culture is 20-30°C and initial pH is preferably 6-8.
Inventors:
ITO TAKASHI
HIDA TSUNEAKI
KITANO KAZUAKI
HIDA TSUNEAKI
KITANO KAZUAKI
Application Number:
JP18245191A
Publication Date:
November 15, 1999
Filing Date:
July 23, 1991
Export Citation:
Assignee:
TAKEDA YAKUHIN KOGYO KK
International Classes:
A61K31/235; A61K31/00; A61P29/00; A61P43/00; C07C69/773; C12N9/99; C12P7/42; C12R1/645; (IPC1-7): C07C69/773; A61K31/00; A61K31/235; C12N9/99; C12P7/42
Attorney, Agent or Firm:
Tadao Asahina