PURPOSE: To obtain a PI3 kinase-inhibiting agent containing a specific didepside as an active ingredient, inhibiting the activation of neutrophile and platelet, and effective as an antitumor agent, an antiinflammatory agent and an antiarteriosclerosis agent.
CONSTITUTION: The inhibiting agent contains a didepside of the formula (R is H, β-D-glucopyranosyl, β-D-galactopyranosyl) as an active ingredient. The didepside is obtained by culturing a coremium-forming fungus D2949 strain (FERM P-14711) belonging to the class of imperfect molds preferably by a submerged culture method using an agar culture medium at about 20-27°C usually for 7-21 days. The didepside is preferably administered at a dose of about 10-2000mg/day for an adult usually in one to four portions.
AZUMA KYOICHIRO
TAKASHIMA JUNKO
CHIBA NORIKO
MIKAWA TAKASHI
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