Title:
α-4インテグリンのピリジノンアンタゴニスト
Document Type and Number:
Japanese Patent JP2012525336
Kind Code:
A
Abstract:
The present invention provides compounds that are alpha4 integrin antagonists having a structure according to the following formula: or a tautomer, mixture of tautomers, salt or solvate thereof, wherein Cy, ring A, m, n, p, R1, R2, R3, R4, R5 and R6 are defined in the specification. The invention further provides pharmaceutical compositions including the compounds of the invention as well as methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various conditions and disorders, such as Crohn's disease and ulcerative colitis.
Inventors:
Sue, In-Twee
Yuan, Shen Dong
Won, David
Conrad, Andrey
Yuan, Shen Dong
Won, David
Conrad, Andrey
Application Number:
JP2012507475A
Publication Date:
October 22, 2012
Filing Date:
April 27, 2010
Export Citation:
Assignee:
Elan Pharmaceuticals, Inc.
International Classes:
C07D213/74; A61K31/4412; A61K31/443; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4709; A61K31/496; A61K31/501; A61K31/506; A61K31/5377; A61P1/04; A61P11/06; A61P19/02; A61P25/00; A61P29/00; A61P35/04; A61P37/06; C07D213/78; C07D401/04; C07D405/04; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D413/12; C07D417/12; C07D417/14; G01N33/15; G01N33/50
Domestic Patent References:
| JP2007505901A | 2007-03-15 | |||
| JP2002544161A | 2002-12-24 | |||
| JP2009526761A | 2009-07-23 |
Foreign References:
| WO2009032277A1 | 2009-03-12 | |||
| WO2007008541A2 | 2007-01-18 | |||
| WO2004046122A2 | 2004-06-03 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita