Title:
PIPERAZINE DERIVATIVES, ITS ACID-ADDED SALTS AND PREPARATION OF THESE
Document Type and Number:
Japanese Patent JPH01153685
Kind Code:
A
Abstract:
NEW MATERIAL: A compound expressed by formula I, wherein (n) is 0 to 3; R is H, OH, acyloxy of OCOR1 (R1 is 1 to 9C alkyl).
EXAMPLE: 2-{4-[2-(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yloxy)- ethyl]piperadin-1-yl}ethanol.
USE: Noncataleptic neurorelaxant. The compd. exhibits a significant in-vivo antidopaminergic activity, low toxicity and no cataleptic or anti-apomorphine properties.
PREPARATION: A reactive ester of 2-[2-chloro-10,11-dihydrodibenzo [b, f]thiepin-10-yloxy]ethanol expressed by formula II (X is halogen except for F, alkane sulfonyloxy, etc.) is allowed to react with a piperazine deriv. expressed by formula III, preferably in DMF in the presence of potassium carbonate. The reaction is preferably carried out at 90 to 100°C.
Inventors:
MIROSURABU PUROTEIBA
IJII IIREKU
MARUCHIN BARUHAAJI
YOSEFU POMIKACHIEKU
NATASHIYAA DOROHOJIKOBAA
IJII IIREKU
MARUCHIN BARUHAAJI
YOSEFU POMIKACHIEKU
NATASHIYAA DOROHOJIKOBAA
Application Number:
JP29111788A
Publication Date:
June 15, 1989
Filing Date:
November 19, 1988
Export Citation:
Assignee:
SPOFA SPOJENE POD PRO ZDRAVOTN
International Classes:
A61K31/495; A61P43/00; C07D337/14; (IPC1-7): A61K31/495; C07D337/14
Attorney, Agent or Firm:
Aoki Akira (3 outside)