Title:
ピペラジニルオキソアルキルテトラヒドロイソキノリン類および関連類似物
Document Type and Number:
Japanese Patent JP2009531314
Kind Code:
A
Abstract:
Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
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Inventors:
Gao Yang
Han Bin Son
Zoo Yulian
Caldwell Timothy M
Zayer Linhong
Han Bin Son
Zoo Yulian
Caldwell Timothy M
Zayer Linhong
Application Number:
JP2009500382A
Publication Date:
September 03, 2009
Filing Date:
March 08, 2007
Export Citation:
Assignee:
Neurogen Corporation
International Classes:
C07D217/04; A61K31/437; A61K31/4725; A61K31/496; A61K31/497; A61K31/4985; A61K31/501; A61K31/5025; A61K31/506; A61K31/519; A61K31/5377; A61K31/55; A61P1/08; A61P3/04; A61P3/10; A61P25/00; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/28; A61P27/16; A61P43/00; C07D217/14; C07D223/16; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D405/04; C07D405/14; C07D413/04; C07D417/04; C07D471/04; C07D487/04; C07D487/08; C07D491/048; C07D495/04; C07D498/04; C07D513/04; C07D519/00; G01N33/53
Attorney, Agent or Firm:
Kenji Yoshida
Jun Ishida
Jun Ishida