Title:
タキキニン受容体拮抗剤としてのピペリジン誘導体
Document Type and Number:
Japanese Patent JP2009502739
Kind Code:
A
Abstract:
The present invention relates to a compound represented by the formula: wherein Ar is a phenyl group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom, a C1-6 alkyl group optionally having substituent(s) or a C3-6 cycloalkyl group optionally having substituent(s), Z is a methylene group optionally having a C1-6 alkyl group, ring A is a piperidine ring optionally further having substituent(s), ring B and ring C are benzene rings optionally further having substituent(s), and R2 optionally form a ring together with the adjacent substituent on the ring B, except the compounds represented by the formula: or a salt thereof. The compound of the present invention has a superior tachykinin receptor antagonistic action, particularly a substance P receptor antagonistic action, and is useful as a pharmaceutical agent, for example, tachykinin receptor antagonist, an agent for the prophylaxis or treatment of lower urinary tract symptoms, gastrointestinal diseases or central nerve diseases.
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Inventors:
Yoshinori Ikeura
Junya Shirai
Takeshi Yoshikawa
Nobutaka Sakauchi
Junya Shirai
Takeshi Yoshikawa
Nobutaka Sakauchi
Application Number:
JP2008505537A
Publication Date:
January 29, 2009
Filing Date:
August 04, 2006
Export Citation:
Assignee:
Takeda GmbH
International Classes:
C07D211/58; A61K31/445; A61K31/454; A61K31/4545; A61P1/00; A61P1/04; A61P1/12; A61P13/02; A61P13/08; A61P13/10; A61P25/00; A61P25/04; A61P25/20; A61P25/22; A61P25/24; A61P43/00; C07D401/06; C07D401/14; C07D413/06
Attorney, Agent or Firm:
Takashima Ichi