PIPERIDINOALKANONES, ITS SALT AND THEIR PREPARATION

Title:

PIPERIDINOALKANONES, ITS SALT AND THEIR PREPARATION

Document Type and Number:

Japanese Patent JPS591467

Kind Code:

A

Abstract:

NEW MATERIAL:1-(4-Hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-one of formula I and its salt.

USE: It is used as a synthetic intermediate of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol, which is used as a medicine for improving a variety of synptoms accompanied with sequelae of cerebral embolism and hemorrage, because of its action of improving cerebral blood flow.

PREPARATION: The condensation reaction between 4-hydroxy-α-halogenopropiophenone of formula II (X is halogen) and 4-benzylpiperidine of formula III is carried out in a solvent, preferably in an alcohol at 30W150°C, preferably 50W 100°C to give the compound of formula I .

Inventors:

KIKAZAWA KAZUO
HIIRAGI MINEJI
AZUMA NAGATOSHI
KOHAGISAWA TOSHITAKA

Application Number:

JP1877583A

Publication Date:

January 06, 1984

Filing Date:

February 09, 1983

Export Citation:

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Assignee:

GRELAN PHARMACEUTICAL CO

International Classes:

C07D211/14; C07C45/00; C07C49/825; C07C67/00; (IPC1-7): C07C49/825; C07D211/14

Domestic Patent References:

JPS4867234A

1973-09-13

Attorney, Agent or Firm:

Shoji Matsui

Next Patent: JPS591468