ピペリジニルスルホニルメチルヒドロキサム酸とピペラジニルスルホニルメチルヒドロキサム酸、ならびにそのプロテアーゼ阻害剤としての利用法

Japanese Patent JP2007510732

A

This invention is directed generally to proteinase (also known as "protease") inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A¹, A², Y, E¹, E², E³, and R^x are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.

Brown, David Elle.
Grappler House, Margaret El.
Casab, Darren Jay.
Massa, Mark A.
McDonald's, Joseph Jay.
Murins, Patrick Bee.
Rico, Joseph G.
Schmidt, Michelle A.

JP2006539634A

April 26, 2007

November 03, 2004

Click for automatic bibliography generation  

Pharmacia Corporation

C07D211/66; A61K31/452; A61K31/4535; A61K31/454; A61K31/4545; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P17/02; A61P19/02; A61P19/08; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P41/00; A61P43/00; C07D211/16; C07D211/22; C07D211/96; C07D213/74; C07D295/18; C07D309/08; C07D335/02; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D405/06; C07D405/12; C07D405/14; C07D407/12; C07D409/04; C07D409/12; C07D409/14; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D417/12; C07D417/14

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura

Previous Patent: Ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト

Next Patent: プロトンポンプ阻害剤および睡眠剤の併用