NEW MATERIAL:The compound of formula I (R1 is H or methyl; R2 and R3 are H, lower alkyl or R2 and R3 together with adjacent N form a heterocyclic group such as aziridinyl, azetidinyl, pyrrolidinyl and morpholino; A is single bond, lower alkylene, lower alkenylene or lower alkynylene).
EXAMPLE: (5R,6S)-2-[(2S,5S)-2-dimethylcarbamoylpiperidin-5-yl]thio-6-[(1R)-1- hydroxyethyl]-1-carbapen-2-em-3-carboxylic acid.
USE: Medicine for microbism such as infectious diseases of respiratory organ and urinary tract, suppurative diseases and surgical infection disease.
PREPARATION: A compound of formula II (R5 is carboxyl-protecting group; Z is eliminable group) is made to react with a compound of formula III and the protective group of the product is removed.
KATO SHINJI
FUKATSU HIROSHI
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