Title:
Piran spirocyclic piperidine amide as a modulator of an ion channel
Document Type and Number:
Japanese Patent JP6215230
Kind Code:
B2
Abstract:
The invention relates to pyran spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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Inventors:
Hadida Rua, Sara Sabina
Alum Gum, Vijayalakusumi
Denino, Michael Paul
Freeman, Brian A.
Karel, Edward Adam
Mirror,mark thomas
Ui, johnny
Elephant, Jinlan
Alum Gum, Vijayalakusumi
Denino, Michael Paul
Freeman, Brian A.
Karel, Edward Adam
Mirror,mark thomas
Ui, johnny
Elephant, Jinlan
Application Number:
JP2014552376A
Publication Date:
October 18, 2017
Filing Date:
January 15, 2013
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07D491/107; A61K31/438; A61K31/444; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/498; A61K31/5377; A61P1/12; A61P9/06; A61P9/10; A61P9/12; A61P13/10; A61P19/02; A61P21/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D519/00
Domestic Patent References:
| JP2014508169A | ||||
| JP2009533353A | ||||
| JP2014508756A |
Foreign References:
| WO2010002483A1 | ||||
| WO2010151597A1 | ||||
| WO2010151815A1 |
Other References:
Walters, Michael A.; La, Frances; Deshmukh, Prashant; Omecinsky, Diana O.,Templates for Exploratory Library Preparation. Derivatization of a Functionalized Spirocyclic 3,6-Dihydro-2H-Pyran Formed by Ring-Closing Metathesis Reaction,Journal of Combinatorial Chemistry,2002年,Vol.4, No.2,pp.125-130
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita