Title:
癌治療用のスプライセオソームターゲティング薬剤としてのプラジエノライド誘導体
Document Type and Number:
Japanese Patent JP7334181
Kind Code:
B2
Abstract:
The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
Inventors:
Cook, Andrew
Reynolds, Dominic
Chung, Chen
brown, ryan
Ellery, Shelby
Samara Kuhn, Siwanka
Ryu, Shan
Prajapati, Sudeep
Sheehan, Meghan
Lowe, Jason Tee.
Palatino, James
Reynolds, Dominic
Chung, Chen
brown, ryan
Ellery, Shelby
Samara Kuhn, Siwanka
Ryu, Shan
Prajapati, Sudeep
Sheehan, Meghan
Lowe, Jason Tee.
Palatino, James
Application Number:
JP2020555482A
Publication Date:
August 28, 2023
Filing Date:
April 11, 2019
Export Citation:
Assignee:
Eisai R&D Management Co., Ltd.
International Classes:
C07D313/00; A61K31/496; A61K31/497; A61K31/506; A61K31/513; A61K31/5377; A61K31/5386; A61K31/541; A61K31/551; A61P35/00; A61P35/02; C07D315/00; C07D405/06; C07D405/10; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D413/10; C07D413/12; C07D413/14; C07D417/10; C07D453/02; C07D471/04; C07D471/10; C07D487/04; C07D491/107; C07D498/08
Domestic Patent References:
| JP2017505282A |
Foreign References:
| WO2007110704A2 | ||||
| WO2002060890A1 | ||||
| WO2008111464A1 | ||||
| WO2008111466A1 | ||||
| US20140275010 |
Other References:
MULLER,S. et al.,Synthesis of a Pladienolide B Analogue with the Fully Functionalized Core Structure,Organic Letters,2011年,Vol.13, No.15,p.3940-3943
Attorney, Agent or Firm:
Yoshiki Hasegawa
Yoshinori Shimizu
Katsusuke Kimoto
Yoshinori Shimizu
Katsusuke Kimoto