Title:
血小板付着インヒビター
Document Type and Number:
Japanese Patent JP3558292
Kind Code:
B2
Abstract:
PCT No. PCT/GB91/01763 Sec. 371 Date Apr. 9, 1993 Sec. 102(e) Date Apr. 9, 1993 PCT Filed Oct. 10, 1991 PCT Pub. No. WO92/07005 PCT Pub. Date Apr. 30, 1992The inhibitor is protein derived leech tissue or leech secretions (for example, from Hirudo medicinalis), which is capable of binding to native collagen, in such a way that substantially no cleavage breakdown products of coilagen molecules occur on SDS-PAGE. The protein substantially inhibits collagen-induced platelet aggregation or adhesion, has a molecular weight of 60-70 kilodaltons in reduced form and has optimum activity at pH 8.0.
Inventors:
Soyer, Roy, Tee.
Application Number:
JP51646791A
Publication Date:
August 25, 2004
Filing Date:
October 10, 1991
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K38/46; A61L33/00; A61P7/02; A61P37/00; A61K38/00; C07K1/00; C07K1/16; C07K1/18; C07K14/435; C07K14/705; (IPC1-7): C07K14/435; A61K38/00; A61K38/46; A61L33/00
Domestic Patent References:
| JP2147067A |
Foreign References:
| WO1990006128A1 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Koji Kikawa
Naganuma Akio
Hajime Asamura
Koji Kikawa
Naganuma Akio