Title:
疾患検出のための血小板バイオマーカー
Document Type and Number:
Japanese Patent JP2007535324
Kind Code:
A
Abstract:
The present inventors have surprisingly discovered that platelets sequester angiogenic regulators and prevent their degradation. Thus, by analyzing levels of angiogenic regulators in platelets, it is now possible to detect angiogenic activity, even at an early stage. By monitoring for changes in angiogenic activity, the presence of cancer or other angiogenic diseases or disorders can be predicted.
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Inventors:
Folkman Juda
Clement Gianola
Clement Gianola
Application Number:
JP2007510873A
Publication Date:
December 06, 2007
Filing Date:
April 26, 2005
Export Citation:
Assignee:
Children's Medical Center Corporation
International Classes:
C12Q1/02; C12Q1/00; G01N33/53; G01N33/574; G01N33/68; G01N33/86; G01N37/00
Other References:
JPN6011006042, Ｓｃａｎｄ Ｊ Ｃｌｉｎ Ｌａｂ Ｉｎｖｅｓｔ．， ６２［５］ （２００２） ｐ．３４３−５０
JPN6011006044, Ｃｌｉｎ Ｃａｎｃｅｒ Ｒｅｓ．， ３ （１９９７） ｐ．２１８７−９０
JPN6011006046, Ｌａｎｃｅｔ， ３５２ （１９９８） ｐ．１７７５−７７
JPN6011006061, Ｊｐｎ Ｊ Ｃｌｉｎ Ｏｎｃｏｌ．， ３４［４］ （２００４．０４） ｐ．１８４−１９０
JPN6011006063, 肺癌， ４１［５］ （２００１） ｐ．４０２ （Ｗ１−４）
JPN6011006066, Ａｎｇｉｏｇｅｎｅｓｉｓ， ４ （２００１） ｐ．３７−４３
JPN6011006068, Ａｍ Ｊ Ｐａｔｈｏｌ．， １６１［１］ （２００２） ｐ．３５−４１
JPN6011006044, Ｃｌｉｎ Ｃａｎｃｅｒ Ｒｅｓ．， ３ （１９９７） ｐ．２１８７−９０
JPN6011006046, Ｌａｎｃｅｔ， ３５２ （１９９８） ｐ．１７７５−７７
JPN6011006061, Ｊｐｎ Ｊ Ｃｌｉｎ Ｏｎｃｏｌ．， ３４［４］ （２００４．０４） ｐ．１８４−１９０
JPN6011006063, 肺癌， ４１［５］ （２００１） ｐ．４０２ （Ｗ１−４）
JPN6011006066, Ａｎｇｉｏｇｅｎｅｓｉｓ， ４ （２００１） ｐ．３７−４３
JPN6011006068, Ａｍ Ｊ Ｐａｔｈｏｌ．， １６１［１］ （２００２） ｐ．３５−４１
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi