Title:
POLYAMINE AND USE OF THE SAME IN THERAPY
Document Type and Number:
Japanese Patent JP2011084586
Kind Code:
A
Abstract:
To develop novel polyamine analogues for various applications.
The present invention provides novel polyamine analogues, compositions comprising these polyamine analogues, and methods of using the analogues and the compositions. In one embodiment, the polyamine analogues are strically configurationally restricted. This invention also relates to use of these analogs or conjugates in various medicinal applications, including suppressing cell proliferation and treating various diseases, including cancer.
Inventors:
FRYDMAN BENJAMIN
MARTON LAURENCE J
REDDY VENODHAR K
VALASINAS ALDONIA
BLOKHIN ANDREI V
BASU HIRAK S
MARTON LAURENCE J
REDDY VENODHAR K
VALASINAS ALDONIA
BLOKHIN ANDREI V
BASU HIRAK S
Application Number:
JP2011017302A
Publication Date:
April 28, 2011
Filing Date:
January 28, 2011
Export Citation:
Assignee:
CELLGATE INC
International Classes:
C07C211/13; A61K31/13; A61K31/132; A61K31/137; A61K31/155; A61K31/40; A61K31/409; A61K47/48; A61P1/04; A61P1/18; A61P9/10; A61P11/00; A61P13/08; A61P13/10; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P25/00; A61P25/08; A61P25/28; A61P31/04; A61P31/10; A61P33/00; A61P35/00; A61P35/02; A61P37/06; C07C45/46; C07C67/343; C07C211/18; C07C211/22; C07C211/23; C07C211/36; C07C215/14; C07C251/18; C07C257/18; C07D207/34; C07D219/10; C07D235/18; C07D295/185; C07D307/79; C07D307/92; C07D311/92; C07D317/70; C07D487/22; C07D493/04; C07K5/103; C07K7/06; A61K38/00
Domestic Patent References:
| JPH07277964A | 1995-10-24 | |||
| JPH01246286A | 1989-10-02 | |||
| JPS62167783A | 1987-07-24 | |||
| JPH08507548A | 1996-08-13 | |||
| JPH02117647A | 1990-05-02 |
Foreign References:
| US5541230A | 1996-07-30 | |||
| WO1998017624A1 | 1998-04-30 |
Other References:
JPN6010026479; ＬＡＵ，Ｈ． ａｎｄ ＧＵＴＳＣＨＥ，Ｃ．Ｄ．: 'Ａｓｓｏｃｉａｔｉｏｎ ｐｈｅｎｏｍｅｎａ． ３． Ｐｏｌｙｆｕｎｃｔｉｏｎａｌ ｃａｔａｌｙｓｉｓ ｏｆ ａｃｅｔｙｌ ｐｈｏｓｐｈａｔｅ ｄｅｃｏｍｐｏｓｉｔｉｏｎ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１００， Ｎｏ．６, 1978, ｐ．１８５７-１８６５
JPN6010026477; ＲＡＪＡＰＰＡ，Ｓ． ａｎｄ ＳＲＥＥＮＩＶＡＳＡＮ，Ｒ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｒｅａｃｔｉｖｉｔｙ ｏｆ ｐｏｌｙａｍｉｎｅｓ： ｐａｒｔ ２ - ｒｅａｃｔｉｖｉｔｙ ｏｆ ｓｕｂｓｔｒａｔｅｓ ｗｉｔｈ ｔｅｒｍｉｎａｌ ａｎｉｌｉｎｅ ｕｎｉ' Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ， Ｓｅｃｔｉｏｎ Ｂ： Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｉｎｃｌｕｄｉｎｇ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２４Ｂ， Ｎｏ．１, 1985, ｐ．１４-１８
JPN6010026474; ＭＥＮＩＦ，Ｒ． ａｎｄ ＭＡＲＴＥＬＬ，Ａ．Ｅ．: '１，３-Ｂｉｓ（２，５，８，１１-ｔｅｔｒａａｚａｕｎｄｅｃｙｌ）ｂｅｎｚｅｎｅ （ＭＸＴＲＩＥＮ）： ｓｙｎｔｈｅｓｉｓ， ｂｉｎｕｃｌｅａｔｉｎｇ ｃｈｅｌａｔｉｎｇ ｔｅｎｄｅｎｃｉｅｓ， ａ' Ｉｎｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２８， Ｎｏ．１, 1989, ｐ．１１６-１２２
JPN6010026472; ＪＡＫＯＢＳ，Ａ． ｅｔ ａｌ．: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ Ｔｅｔｒａｃａｔｉｏｎｉｃ Ｍｅｔａｌｌｏｐｏｒｐｈｙｒｉｎ-Ｓｐｅｒｍｉｎｅ Ｃｏｎｊｕｇａｔｅｓ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６２， Ｎｏ．１１, 1997, ｐ．３５０５-３５１０
JPN6010026470; ＨＵＡＮＧ，Ｄ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ｐｈｉｌａｎｔｈｏｔｏｘｉｎ ａｎａｌｏｇｓ ｗｉｔｈ ｂｕｌｋｙ ｈｅａｄｓ ｉｎｃｌｕｄｉｎｇ ｐｏｒｐｈｙｒｉｎｓ． Ｓｅｌｆ-ａｓｓｅｍｂｌｙ ｍｏｎｉｔｏｒｅｄ ｂ' Ｈｅｔｅｒｏｃｙｃｌｅｓ Ｖｏｌ．４２， Ｎｏ．２, 1996, ｐ．７２３-７３６
JPN6010026469; ＲＥＤＤＹ，Ｖ．Ｋ． ｅｔ ａｌ．: 'Ｃｏｎｆｏｒｍａｔｉｏｎａｌｌｙ Ｒｅｓｔｒｉｃｔｅｄ Ａｎａｌｏｇｓ ｏｆ １Ｎ，１２Ｎ-Ｂｉｓｅｔｈｙｌｓｐｅｒｍｉｎｅ： Ｓｙｎｔｈｅｓｉｓ ａｎｄ Ｇｒｏｗｔｈ Ｉｎｈｉｂｉｔｏｒｙ Ｅｆｆｅ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４１， Ｎｏ．２４, 1998, ｐ．４７２３-４７３２
JPN6010026466; ＷＵＮＺ，Ｔ．Ｐ． ｅｔ ａｌ．: 'Ｎｅｗ ａｎｔｉｔｕｍｏｒ ａｇｅｎｔｓ ｃｏｎｔａｉｎｉｎｇ ｔｈｅ ａｎｔｈｒａｃｅｎｅ ｎｕｃｌｅｕｓ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３０， Ｎｏ．８, 1987, ｐ．１３１３-１３２１
JPN6010026477; ＲＡＪＡＰＰＡ，Ｓ． ａｎｄ ＳＲＥＥＮＩＶＡＳＡＮ，Ｒ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｒｅａｃｔｉｖｉｔｙ ｏｆ ｐｏｌｙａｍｉｎｅｓ： ｐａｒｔ ２ - ｒｅａｃｔｉｖｉｔｙ ｏｆ ｓｕｂｓｔｒａｔｅｓ ｗｉｔｈ ｔｅｒｍｉｎａｌ ａｎｉｌｉｎｅ ｕｎｉ' Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ， Ｓｅｃｔｉｏｎ Ｂ： Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｉｎｃｌｕｄｉｎｇ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２４Ｂ， Ｎｏ．１, 1985, ｐ．１４-１８
JPN6010026474; ＭＥＮＩＦ，Ｒ． ａｎｄ ＭＡＲＴＥＬＬ，Ａ．Ｅ．: '１，３-Ｂｉｓ（２，５，８，１１-ｔｅｔｒａａｚａｕｎｄｅｃｙｌ）ｂｅｎｚｅｎｅ （ＭＸＴＲＩＥＮ）： ｓｙｎｔｈｅｓｉｓ， ｂｉｎｕｃｌｅａｔｉｎｇ ｃｈｅｌａｔｉｎｇ ｔｅｎｄｅｎｃｉｅｓ， ａ' Ｉｎｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２８， Ｎｏ．１, 1989, ｐ．１１６-１２２
JPN6010026472; ＪＡＫＯＢＳ，Ａ． ｅｔ ａｌ．: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ Ｔｅｔｒａｃａｔｉｏｎｉｃ Ｍｅｔａｌｌｏｐｏｒｐｈｙｒｉｎ-Ｓｐｅｒｍｉｎｅ Ｃｏｎｊｕｇａｔｅｓ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６２， Ｎｏ．１１, 1997, ｐ．３５０５-３５１０
JPN6010026470; ＨＵＡＮＧ，Ｄ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ｐｈｉｌａｎｔｈｏｔｏｘｉｎ ａｎａｌｏｇｓ ｗｉｔｈ ｂｕｌｋｙ ｈｅａｄｓ ｉｎｃｌｕｄｉｎｇ ｐｏｒｐｈｙｒｉｎｓ． Ｓｅｌｆ-ａｓｓｅｍｂｌｙ ｍｏｎｉｔｏｒｅｄ ｂ' Ｈｅｔｅｒｏｃｙｃｌｅｓ Ｖｏｌ．４２， Ｎｏ．２, 1996, ｐ．７２３-７３６
JPN6010026469; ＲＥＤＤＹ，Ｖ．Ｋ． ｅｔ ａｌ．: 'Ｃｏｎｆｏｒｍａｔｉｏｎａｌｌｙ Ｒｅｓｔｒｉｃｔｅｄ Ａｎａｌｏｇｓ ｏｆ １Ｎ，１２Ｎ-Ｂｉｓｅｔｈｙｌｓｐｅｒｍｉｎｅ： Ｓｙｎｔｈｅｓｉｓ ａｎｄ Ｇｒｏｗｔｈ Ｉｎｈｉｂｉｔｏｒｙ Ｅｆｆｅ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４１， Ｎｏ．２４, 1998, ｐ．４７２３-４７３２
JPN6010026466; ＷＵＮＺ，Ｔ．Ｐ． ｅｔ ａｌ．: 'Ｎｅｗ ａｎｔｉｔｕｍｏｒ ａｇｅｎｔｓ ｃｏｎｔａｉｎｉｎｇ ｔｈｅ ａｎｔｈｒａｃｅｎｅ ｎｕｃｌｅｕｓ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３０， Ｎｏ．８, 1987, ｐ．１３１３-１３２１
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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