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Title:
POLYAMINE AND USE OF THE SAME IN THERAPY
Document Type and Number:
Japanese Patent JP2011084586
Kind Code:
A
Abstract:

To develop novel polyamine analogues for various applications.

The present invention provides novel polyamine analogues, compositions comprising these polyamine analogues, and methods of using the analogues and the compositions. In one embodiment, the polyamine analogues are strically configurationally restricted. This invention also relates to use of these analogs or conjugates in various medicinal applications, including suppressing cell proliferation and treating various diseases, including cancer.


Inventors:
Frydman, Benjamin
Marton, Laurence J.
Reddy, Venodhar K.
Valasinas, Aldonia
Blokhin, Andrei V.
Basu, Hirak S.
Application Number:
JP2011000017302
Publication Date:
April 28, 2011
Filing Date:
January 28, 2011
Export Citation:
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Assignee:
CELLGATE INC
International Classes:
C07C211/13; A61K31/13; A61K31/132; A61K31/137; A61K31/155; A61K31/40; A61K31/409; A61K47/48; A61P1/04; A61P1/18; A61P9/10; A61P11/00; A61P13/08; A61P13/10; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P25/00; A61P25/08; A61P25/28; A61P31/04; A61P31/10; A61P33/00; A61P35/00; A61P35/02; A61P37/06; C07C45/46; C07C67/343; C07C211/18; C07C211/22; C07C211/23; C07C211/36; C07C215/14; C07C251/18; C07C257/18; C07D207/34; C07D219/10; C07D235/18; C07D295/185; C07D307/79; C07D307/92; C07D311/92; C07D317/70; C07D487/22; C07D493/04; C07K5/103; C07K7/06; A61K38/00
Domestic Patent References:
1995-10-24
1989-10-02
1987-07-24
1996-08-13
1990-05-02
Foreign References:
US5541230A1996-07-30
WO1998017624A11998-04-30
Other References:
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JPN6010026477; RAJAPPA,S. and SREENIVASAN,R.: 'Synthesis and reactivity of polyamines:  part 2 - reactivity of substrates with terminal aniline uni' Indian Journal of Chemistry, Section B:  Organic Chemistry Including Medicinal Chemistry Vol.24B, No.1, 1985, p.14-18
JPN6010026474; MENIF,R. and MARTELL,A.E.: '1,3-Bis(2,5,8,11-tetraazaundecyl)benzene (MXTRIEN):  synthesis, binucleating chelating tendencies, a' Inorganic Chemistry Vol.28, No.1, 1989, p.116-122
JPN6010026472; JAKOBS,A. et al.: 'Preparation of Tetracationic Metalloporphyrin-Spermine Conjugates' Journal of Organic Chemistry Vol.62, No.11, 1997, p.3505-3510
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