PURPOSE: To provide a cerebrovascular agent for treatment of neurodegenerative disorders including cerebrovascular diseases, comprising a polycyclic amine such as aminomethylhexahydrophenanthrene.
CONSTITUTION: A compound of the formula [R1 and R2 are each H, an alkyl, alkenyl, arylalkyl or a pharmaceutically acceptable labile group, or R1 and R2 together form a heterocyclic ring; R3 and R4 are each H, an alkyl, OH, alkoxy, halogen, NH2, mono or dialkylamino, etc.; ring A may be thiophene; R5 and R6 are each H, an alkyl, alkenyl, OH, aldehyde, alkylcarbonyl, etc.; X' is CH2, O, S, etc.; X is CR7R8, CR7R8CH2, CR7=CR8, CHR7S, etc. (R7 and R8 are each H, an alkyl, OH, methoxy, etc.); n is 0 to 2], e.g. 1,3,4,10a- tetrahydro-N-2-propenyl-4a(2H)-phenanthreneamine, is incorporated as an active ingredient.
SHIERIRU JIIN HEIZU
GUREIAMU JIYONSON
PERII MAIKURU NOOBAKU
DANIERU FURETSUDO OOTOWAIN
